Publications (PDF)
 

Peer-reviewed Publications

H-index: 24

2012

Smittenaar P, Chase HW, Aarts E, Nusselein B, Bloem BR, Cools R
Decomposing effects of dopaminergic medication in Parkinson's disease on probabilistic action selection: learning or performance? Eur J Neuroscience. [journal impact: 3.4]. In press

2011

Aarts E, Helmich R, Janssen M, Oyen W, Bloem B, Cools R
Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss.

NeuroImage. [journal impact: 5.7]. In press

 

Robinson OJ, Cools R, Carlisi CO, Sahakian BJ, Drevets WC (2011). Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder.

Am J Psychiatry. [journal impact: 12.5]. PubMed.

 

van der Schaaf M, Warmerdam E, Crone E, Cools R (in press). Distinct linear and non-linear trajectories of reward and punishment reversal learning during development: Relevance for dopamine's role in adolescent decision making.

Developmental Cognitive Neuroscience

Aarts E, van Holstein M, Cools R (2011). Striatal dopamine and the interface between motivation and cognition.
Frontiers in Psychology. PubMed.

Robinson OJ, Cools R, Sahakian BJ (2011). Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience.
Psychopharmacology [journal impact: 4.1]. PubMed.

Hoogman M, Aarts E, Zwiers M, Slaats-Willemse D, Naber M, Cools R, Kan C, Buitelaar J, Franke B (2011). Nitric Oxide Synthase genotype modulation of impulsivity and ventral striatal activity in Attention Deficit/Hyperactivity Disorder and comparison subjects.
Am J Psychiatr. [journal impact: 12.5]. PubMed.

Cools R (2011). Dopaminergic control of the striatum for high-level cognition.
Curr Opin Neurobiol. [journal impact: 7.2]. PubMed.

van Holstein M, Aarts E, van der Schaaf M, Geurts D, Verkes R-J, Franke B, van Schouwenburg M, Cools R (2011). Human cognitive flexibility depends on dopamine D2 receptor signaling.
Psychopharmacology [journal impact: 4.1]. PubMed.

Cools R and D’Esposito M (2011). Inverted U-shaped dopamine actions on human working memory and cognitive control.
Biol Psychiatry
[journal impact: 8.9]. PubMed.

Chase HW, Swainson R, Durham L, Benham L, Cools R (2011). Feedback-related negativity codes prediction error but not behavioural adjustment during probabilistic reversal learning.
J Cogn Neurosci. [journal impact: 5.4]. PubMed.

Huys, QJM, Cools R, Goelzer M, Friedel E, Heinz A, Dolan RJ, Dayan P (2011). Disentangling the roles of approach, activation and valence in instrumental and pavlovian responding.
PLoS Computational Biology [journal impact: 5.6]. PubMed.

De Wit S, Barker RA, Dickinson AD, Cools R (2011). Habitual versus goal-directed action control in Parkinson's disease.
J Cogn Neurosci. 23: 1218-29. [journal impact: 5.4]. PubMed.

Cools R, Nakamura K, Daw ND (2011): Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions.
Neuropsychopharmacology Reviews 36: 98-113. [journal impact: 7.0]. PubMed.

 

2010

Van Schouwenburg M, Den Ouden H, Cools R (2010). The human basal ganglia modulate fronto-posterior connectivity during attention shifting.
J Neurosci 30: 9910- 9918. [journal impact: 8.7]

Aarts E, Roelofs A, Franke B, Rijpkema M, Fernández G, Helmich RC, Cools R (2010). Striatal dopamine mediates the interface between motivational and cognitive control in humans: Evidence from genetic imaging.
Neuropsychopharmacology 35: 1943-1951. [journal impact: 7.0]

Van Schouwenburg M, Aarts E, Cools R (2010). Dopaminergic modulation of cognitive control: Distinct roles for the prefrontal cortex and the basal ganglia.
Curr Pharm Des 16(18): 2026-32. [journal impact: 4.4]

Robinson OJ, Frank MJ, Sahakian BJ, Cools R (2010). Dissociable responses to punishment in distinct striatal regions during reversal learning.
Neuroimage 51: 1459-1467. [journal impact: 5.7]

Robinson O, Standing H, DeVito E, Cools R, Sahakian B (2010): Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males.
Psychopharmacology 211: 187-195. [journal impact: 4.1]

Robinson O.J, Cools R, Crockett M, Sahakian BJ (2010). Mood State moderates the role of serotonin in cognitive biases.
J Psychopharmacology 24: 573-583. [journal impact: 3.6]

Cools R, Miyakawa A, Sheridan M, D'Esposito M (2010). Enhanced frontal function in Parkinson's disease.
Brain 133: 225-33. [journal impact: 9.5]

Cools R, Rogers R, Barker RA, Robbins TW (2010). Top-down attentional control in Parkinson’s disease: salient considerations.
J Cogn Neurosci 22(5): 848-59.[journal impact: 5.4]

 

2009

Cools R, Frank MF, Gibbs SE, Miyakawa A, Jagust W, D'Esposito M (2009). Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration.
J Neurosci
29: 1538-1543. [journal impact: 8.7]

Clatworthy P, Lewis S, Brichard L, Hong Y, Izquierdo D, Clark L, Cools R, Aigbirhio F, Baron J-C, Fryer T, Robbins TW (2009). Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.
J Neurosci 29(15): 4690-6. [journal impact: 8.7]

Kehagia A.A., Cools R, Barker R.A., Robbins T.W (2009). Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson’s disease.
Neuropsychologia 47(4): 1117-27. [journal impact: 4.3]

Rajah MN, Bastianetto S, Bromley-Brits K, Cools R, D'Esposito M, Grady C, Poirier J, Quirion R, Raz N, Song W, Pruesnner J (2009). Biological changes associated with healthy versus pathological aging: A symposium review.
Ageing Research Reviews 8(2): 140-6. [journal impact: 5.6]

Ragland J.D., Cools R., Frank M., Pizzagalli D.A., Preston A., Ranganath C.,Wagner A.D (2009). CNTRICS Final Task Selection: Long-term Memory.
Schiz Bull, 35(1): 197-212. [journal impact: 7.5]

 

2008

Murray GK, Clark L, Corlett PR, Blackwell AD, Cools R, Jones PB, Robbins TW, Poustka L (2008). Incentive motivation in first-episode psychosis: a behavioural study.
BMC Psychiatry 8:34. [journal impact: 1.9]

Dodds C, Müller U, Clark L, van Loon A, Cools R, Robbins TW (2008). Methylphenidate has differential effects on BOLD signal related to cognitive sub-processes of reversal learning.
J Neurosci 28(23): 5976-82. [journal impact: 8.7]

Cools R (2008). Role of dopamine in the motivational and cognitive control of behaviour.
Neuroscientist 14(4): 381-95. [journal impact: 5.7]

Cools R, Gibbs SE, Miyakawa A, Jagust W, D'Esposito M (2008).Working memory capacity predicts dopamine synthesis capacity in the human striatum.
J Neurosci 28(5): 1208-12. [journal impact: 8.7]

Cools R, Roberts AC, Robbins TW (2008). Serotoninergic regulation of emotional and behavioural control processes.
Trends Cogn Sci 12(1): 31-40. [journal impact: 11.7]

Cools R, Robinson OJ, Sahakian BJ (2008). Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction.
Neuropsychopharmacology 33(9): 2291-9. [journal impact: 7.0]

 

2007

Cools R, Sheridan M, Jacobs EJ, D’Esposito MD (2007). Impulsive personality predicts dopamine-dependent changes in fronto-striatal activity during component processes of working memory.
J Neurosci 27(20): 5506-5514. [journal impact: 8.7]

Cools R, Lewis SGJ, Clark L, Barker RA, Robbins TW (2007). L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson’s disease.
Neuropsychopharmacology 32 (1): 180-189. [journal impact: 7.0]

 

2006

Cools R, Ivry RB, D’Esposito M (2006). The human striatum is necessary for responding to changes in stimulus relevance.
J Cogn Neurosci 18: 1973-1983. [journal impact: 5.4]

Funkiewiez A, Ardouin C, Cools R, Krack P, Fraix V, Batir A, Chabardès S, Benabid AL, Robbins TW, Pollak P (2006). Effects of levodopa and bilateral STN stimulation on cognitive and affective functioning of cortico-striatal ‘loops’.
Mov Disorders 21: 1656-1662. [journal impact: 4.0]

Cools R, Altamirano L, D’Esposito M (2006). Reversal learning in Parkinson’s disease depends on medication status and outcome valence.
Neuropsychologia 44 (10): 1663-1673. [journal impact:4.3]

Roiser JP, Blackwell AD, Cools R, Clark L, Rubinsztein DC, Robbins TW, Sahakian BJ (2006). Serotonin transporter polymorphism mediates vulnerability to loss of motivated action following acute tryptophan depletion.
Neuropsychopharmacology 31 (10): 2264-2272. [journal impact: 7.0]

Cools R (2006) Dopaminergic modulation of cognitive function – Implication for L-DOPA therapy in Parkinson’s disease.
Neurosci Biobehav Rev 30 (1): 1-34. [journal impact: 7.8]

 

2005

Cools R, Calder AJ, Lawrence AD, Clark L, Bullmore E, Robbins TW (2005). Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces.
Psychopharmacology 180: 670-679. [journal impact: 4.1]

Cools R, Blackwell A, Clark L, Menzies L, Cox S, Robbins TW (2005). Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity.
Neuropsychopharmacology 30 (7): 1362-1373. [journal impact: 7.0]

Evers EAT, Cools R, Clark L, van der Veen FM, Jolles J, Sahakian BJ, Robbins TW (2005). Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning.
Neuropsychopharmacology 30 (6): 1138-1147. [journal impact: 7.0]

Clark L, Roiser JP, Cools R, Rubinsztein DC, Sahakian BJ, Robbins TW (2005). Stop signal response inhibition in not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity.
Psychopharmacology 182 (2005): 570-578. [journal impact: 4.1]

 

2004

Cools R, Robbins TW (2004). Chemistry of the Adaptive Mind.
Philos Transact Ser A Math Phys Eng Sci 362 (1825): 2871-2888. [journal impact: 2.3]

Cools R, Clark L, Robbins TW (2004). Differential responses in human striatum and prefrontal cortex to changes in object- and rule-relevance.
J Neurosci 24: 1129-35. [journal impact: 8.7]
 
Clark L, Cools R, Robbins T W (2004) The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning.
Brain Cogn 55: 41-53. [journal impact: 2.9]

 

2003

Cools R, Barker R A, Sahakian B J, Robbins T W (2003). L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson’s disease.
Neuropsychologia 41: 1431-1441. [journal impact: 4.3]

Lewis SJG, Cools R, Robbins TW, Dove A, Barker RA, Owen AM (2003). Using executive heterogeneity to explore the nature of working memory deficits in Parkinson’s disease. Neuropsychologia 41: 645-652. [journal impact: 4.3]

 

2002

Cools R, Clark L, Owen AM, Robbins TW (2002). Defining the neural mechanisms of probabilistic reversal learning using event-related functional MRI.
J Neurosci 22: 4563-4567. [journal impact: 8.7]

Cools R, Stefanova E, Barker RA, Robbins TW, Owen AM (2002) Dopaminergic modulation of high-level cognition in Parkinson’s disease: The role of prefrontal cortex revealed by PET.
Brain 125: 584-594.[journal impact: 9.5]

 

2001

Cools R, Barker RA, Sahakian BJ, and Robbins TW (2001). Mechanisms of cognitive set flexibility in Parkinson’s disease.
Brain 124: 2503-2512. [journal impact: 9.5]

Cools R, Barker RA, Sahakian BJ, Robbins TW (2001). Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands.
Cereb Cortex 11: 1136-1143. [journal impact:7.0]

 

2000

Cools R, Brouwer WH, de Jong R, Slooff C (2000). Flexibility, inhibition, and planning: frontal dysfunctioning in schizophrenia.
Brain Cogn 43: 108-12. [journal impact: 2.9]

 

1999

De Jong R, Berendsen E, Cools R (1999). Goal neglect and inhibitory limitations: dissociable causes of interference effects in conflict situations.
Acta Psychologica 101: 379-94

 

Chapters

Cools R, Aarts E, Mehta M (in press): Paradoxical Effects of Drugs on Cognitive Function: The Neuropsychopharmacology of Dopamine and Other Neurotransmitter Systems.
In: Kapur N editor. The Paradoxical Brain. Cambridge: Cambridge University Press.

Cools R (in press) Role of striatal dopamine in the fast adaption of outcome-based decisions.
In: Attention and Performance: Decision making. Eds E Phelps, M Delgado, Robbins TW

Cools R (2010). Short-Term and Working Memory in Humans.
In: Encyclopedia of Psychopharmacology. Ed. Ian P Stolerman. Springer‐Verlag Berlin Heidelberg 2010. DOI 10.1007/978-3-540-68706-1. Pp 1233-1237

Cools R and D’Esposito (2010). Dopaminergic modulation of flexible cognitive control in humans.
In: Dopamine handbook. Eds A Björklund, S Dunnett, L Iversen, S Iversen. Oxford University Press. pp 249-260.

Cools R (2006) Dopaminergic modulation of flexible cognitive control: The role of the striatum.
In: The neuroscience of rule-guided behavior. Eds. S. A Bunge, J. D.Wallis.

Cools R (2006) Dopaminergic modulation of cognitive flexibility: The role of the striatum.
In: Mental Dysfunction in Parkinson’s disease III. Eds. E. Ch. Wolters, H.W., Berendse and C.J. Stam. Amsterdam: VU University Press.

Robbins TW, Crofts HS, Cools R, Roberts AC (2004) Catecholamines and Cognition: Bridging the Gap Between Animal Studies and the Clinical Syndromes.
In: Mental and Behavioral Dysfunction in Movement Disorders. Eds E-A Bedard et al. Humana Press Inc., Totowa, NJ: 183-200.

Cools R and Roberts A. C (2004). The role of dopamine in cognition: Insights from neuropsychological studies in humans and non-human primates.
In: Prefrontal Cortex: from Synapse to Cognition. Ed. S. Otani: 219-243.

Cools R, Swainson R, Owen AM, Robbins TW (1999). Cognitive Dysfunction in non-demented Parkinson’s disease.
In: Mental Dysfunction in Parkinson’s disease. Eds. E.Ch. Wolters, Ph Scheltens, M W Berendse. Utrecht: Academic Pharmaceutical Productions bv.